Dolutegravir
Dolutegravir is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM in a cell-free assay, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
| Trivial name | GSK1349572,S/GSK1349572 |
| Catalog Number | S2667 |
| Molecular Formula | C29H30N8O5.HCl |
| CAS# | 1051375-16-6 |
| Inchi | InChI=1S/C29H30N8O5.ClH/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36;/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H, 32,38);1H |
| Inchi Key | UYKVMFKKKLLDGL-UHFFFAOYSA-N |
| SMILES | CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6.Cl |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/s-gsk1349572.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK1349572-GSK1349572-chemical-structure-s2667.gif |