Dolutegravir
Dolutegravir is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM in a cell-free assay, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
| Trivial name | GSK1349572,S/GSK1349572 |
| Catalog Number | S2667 |
| Molecular Formula | C20H19F2N3O5 |
| CAS# | 1051375-16-6 |
| Inchi | InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1 |
| Inchi Key | RHWKPHLQXYSBKR-BMIGLBTASA-N |
| SMILES | CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/s-gsk1349572.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK1349572-GSK1349572-chemical-structure-s2667.gif |