Dolutegravir
Dolutegravir is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM in a cell-free assay, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
| Trivial name | GSK1349572,S/GSK1349572 |
| Catalog Number | S2667 |
| Molecular Formula | C22H21N3O3S |
| CAS# | 1051375-16-6 |
| Inchi | InChI=1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27) |
| Inchi Key | QBNZBMVRFYREHK-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C4=CC=CC=C4 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/s-gsk1349572.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK1349572-GSK1349572-chemical-structure-s2667.gif |