ICG-001
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.
| Catalog Number | S2662 |
| Molecular Formula | C33H32N4O4 |
| CAS# | 780757-88-2 (relative stereochemistry); 847591-62-2 (absolute stereochemistry) |
| Inchi | InChI=1S/C33H32N4O4/c38-27-15-13-23(14-16-27)19-29-32(40)35(21-26-11-6-10-25-9-4-5-12-28(25)26)22-30-36(18-17-31(39)37(29)30)33(41)34-20-24-7-2-1-3-8-24/h1-16,29-30,38H,17-22H2,(H,34,41)/t29-,30+/m0/s 1 |
| Inchi Key | HQWTUOLCGKIECB-XZWHSSHBSA-N |
| SMILES | C1CN(C2CN(C(=O)C(N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/icg-001.html |
| Additional Information | https://file.selleck.cn/downloads/struct/icg001-chemical-structure-s2662.gif |