Omipalisib (GSK2126458)
Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy. Phase 1.
| Trivial name | GSK458 |
| Catalog Number | S2658 |
| Molecular Formula | C25H17F2N5O3S |
| CAS# | 1086062-66-9 |
| Inchi | InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3 |
| Inchi Key | CGBJSGAELGCMKE-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/gsk2126458.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK2126458-chemical-structure-s2658.gif |