OSI-027
OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.
| Trivial name | ASP4786, CERC 006, AEVI-006 |
| Catalog Number | S2624 |
| Molecular Formula | C20H21F3N8O3S |
| CAS# | 936890-98-1 |
| Inchi | InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30) |
| Inchi Key | FWLMVFUGMHIOAA-UHFFFAOYSA-N |
| SMILES | CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/OSI027.html |
| Additional Information | https://file.selleck.cn/downloads/struct/OSI-027-chemical-structure-S2624.gif |