Silmitasertib (CX-4945)
Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2.
| Trivial name | N/A |
| Catalog Number | S2248 |
| Molecular Formula | C17H30N2O5 |
| CAS# | 1009820-21-6 |
| Inchi | InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1 |
| Inchi Key | SRVFFFJZQVENJC-IHRRRGAJSA-N |
| SMILES | CCOC(=O)C1C(O1)C(=O)NC(CC(C)C)C(=O)NCCC(C)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/cx-4945-silmitasertib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/CX-4945-chemical-structure-S2248.gif |