Volasertib
Volasertib is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3.
| Trivial name | BI 6727 |
| Catalog Number | S2235 |
| Molecular Formula | C15H27N5O5 |
| CAS# | 755038-65-4 |
| Inchi | InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10+,11+/m0/s1 |
| Inchi Key | LTLYEAJONXGNFG-HBNTYKKESA-N |
| SMILES | CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/BI6727-Volasertib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BI6727-Volasertib-chemical-structure-S2235.gif |