Idelalisib (CAL-101)
Idelalisib (CAL-101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy.
| Trivial name | GS-1101 |
| Catalog Number | S2226 |
| Molecular Formula | C18H12Cl2N4O4S |
| CAS# | 870281-82-6 |
| Inchi | InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14+ |
| Inchi Key | KFRKRECSIYXARE-HYARGMPZSA-N |
| SMILES | C1=CC=C(C(=C1)CC(=NNC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)[N+](=O)[O-] |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/CAL-101.html |
| Additional Information | https://file.selleck.cn/downloads/struct/CAL-101-chemical-structure-S2226.gif |