R406
R406(R406 besylate) is a potent Syk inhibitor with IC50 of 41 nM in cell-free assays, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. R406 induces apoptosis. Phase 1.
| Trivial name | R406 besylate |
| Catalog Number | S2194 |
| Molecular Formula | C24H27N7O |
| CAS# | 841290-81-1 |
| Inchi | InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28) |
| Inchi Key | ZYVXTMKTGDARKR-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=CC(=N3)C4=CN(C5=C4C=CN=C5)C)OC |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/R406.html |
| Additional Information | https://file.selleck.cn/downloads/struct/R406-chemical-structure-S2194.gif |