Sapitinib (AZD8931)
Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.
| Trivial name | N/A |
| Catalog Number | S2192 |
| Molecular Formula | C23H25ClFN5O3 |
| CAS# | 848942-61-0 |
| Inchi | InChI=1S/C23H25ClFN5O3/c1-26-21(31)12-30-8-6-14(7-9-30)33-20-10-15-18(11-19(20)32-2)27-13-28-23(15)29-17-5-3-4-16(24)22(17)25/h3-5,10-11,13-14H,6-9,12H2,1-2H3,(H,26,31)(H,27,28,29) |
| Inchi Key | DFJSJLGUIXFDJP-UHFFFAOYSA-N |
| SMILES | CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/AZD8931.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AZD8931-chemical-structure-S2192.gif |