Ixazomib Citrate (MLN9708) Analogue

Ixazomib Citrate (MLN9708) Analogue is the analogue of Ixazomib Citrate (MLN9708) from WO2016165677A1. Ixazomib Citrate (MLN9708) immediately hydrolyzed to Ixazomib (MLN2238), the biologically active form, on exposure to aqueous solutions or plasma. Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Ixazomib (MLN2238) induces autophagy. Phase 3.

Price Not Available 50mg Ixazomib Citrate (MLN9708) Analogue Supplier Page

Trivial name	N/A
Catalog Number	S2181
Molecular Formula	C20H23BCl2N2O9
CAS#	1201902-80-8
Inchi	InChI=1S/C20H23BCl2N2O9/c1-10(2)5-14(21-33-17(29)8-20(34-21,19(31)32)7-16(27)28)25-15(26)9-24-18(30)12-6-11(22)3-4-13(12)23/h3-4,6,10,14H,5,7-9H2,1-2H3,(H,24,30)(H,25,26)(H,27,28)(H,31,32)/t14-,20?/m0 /s1
Inchi Key	YTXSYWAKVMZICI-PVCZSOGJSA-N
SMILES	B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)C(CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl
Size	50mg
Supplier Page	http://www.selleckchem.com/products/MLN9708.html
Additional Information	https://file.selleck.cn/downloads/struct/MLN9708-chemical-structure-S2181.gif