Ixazomib (MLN2238)

Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3.

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Trivial name	N/A
Catalog Number	S2180
Molecular Formula	C14H19BCl2N2O4
CAS#	1072833-77-2
Inchi	InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1
Inchi Key	MXAYKZJJDUDWDS-LBPRGKRZSA-N
SMILES	B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O
Size	5mg
Supplier Page	http://www.selleckchem.com/products/MLN-2238.html
Additional Information	https://file.selleck.cn/downloads/struct/MLN2238-chemical-structure-S2180.gif