Gandotinib (LY2784544)
Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.
| Trivial name | N/A |
| Catalog Number | S2179 |
| Molecular Formula | C23H25ClFN7O |
| CAS# | 1229236-86-5 |
| Inchi | InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4,9,11-12H,5-8,10,13H2,1-2H3,(H2,27,28,29,30) |
| Inchi Key | SQSZANZGUXWJEA-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/LY2784544.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LY2784544-chemical-structure-S2179.gif |