PF-4708671
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.
| Trivial name | N/A |
| Catalog Number | S2163 |
| Molecular Formula | C19H21F3N6 |
| CAS# | 1255517-76-0 |
| Inchi | InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26) |
| Inchi Key | FBLPQCAQRNSVHB-UHFFFAOYSA-N |
| SMILES | CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/pf-4708671.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-4708671-chemical-structure-s2163.gif |