Neratinib
Neratinib is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.
| Trivial name | HKI-272 |
| Catalog Number | S2150 |
| Molecular Formula | C17H16N4O2S2 |
| CAS# | 698387-09-6 |
| Inchi | InChI=1S/C17H16N4O2S2/c1-20-13-7-14(25(2)23)24-16(13)12-8-19-21(17(22)15(12)20)9-10-4-3-5-11(18)6-10/h3-8H,9,18H2,1-2H3 |
| Inchi Key | ZWKJWVSEDISQIS-UHFFFAOYSA-N |
| SMILES | CN1C2=C(C3=C1C(=O)N(N=C3)CC4=CC(=CC=C4)N)SC(=C2)S(=O)C |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/Neratinib(HKI-272).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Neratinib-HKI-272-chemical-structure-S2150.gif |