Lapatinib
Lapatinib is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. Lapatinib induces ferroptosis and autophagic cell death.
| Trivial name | GSK572016, GW2016 |
| Catalog Number | S2111 |
| Molecular Formula | C18H25N7O |
| CAS# | 231277-92-2 |
| Inchi | InChI=1S/C18H25N7O/c1-10-7-8-15(21-11(10)2)23-14-9-16(24-25-17(14)18(20)26)22-13-6-4-3-5-12(13)19/h7-9,12-13H,3-6,19H2,1-2H3,(H2,20,26)(H2,21,22,23,24)/t12-,13+/m0/s1 |
| Inchi Key | XJZVCDVZCRLIKN-QWHCGFSZSA-N |
| SMILES | CC1=C(N=C(C=C1)NC2=CC(=NN=C2C(=O)N)NC3CCCCC3N)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/lapatinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Lapatinib-chemical-structure-s2111.gif |