Pioglitazone HCl
Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.
| Trivial name | AD-4833, U-72107E |
| Catalog Number | S2046 |
| Molecular Formula | C25H16ClN7O3S |
| CAS# | 112529-15-4 |
| Inchi | InChI=1S/C25H16ClN7O3S/c1-37(34,35)18-10-11-20(28-15-18)24-31-29-22(33(24)21-5-3-2-4-19(21)26)12-13-23-30-32-25(36-23)17-8-6-16(14-27)7-9-17/h2-13,15H,1H3/b13-12+ |
| Inchi Key | HIWVLHPKZNBSBE-OUKQBFOZSA-N |
| SMILES | CS(=O)(=O)C1=CN=C(C=C1)C2=NN=C(N2C3=CC=CC=C3Cl)C=CC4=NN=C(O4)C5=CC=C(C=C5)C#N |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/pioglitazone-hydrochloride-actos.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pioglitazone-hydrochloride-actos-chemical-structure-s2046.gif |