BIX 02189
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
| Trivial name | N/A |
| Catalog Number | S1531 |
| Molecular Formula | C27H28N4O2 |
| CAS# | 1094614-85-3 |
| Inchi | InChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,28H,17H2,1-4H3,(H,29,32)/b25-24- |
| Inchi Key | HOMJAAIVTDVQJA-IZHYLOQSSA-N |
| SMILES | CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N(C)C)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/BIX-02189.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BIX02189-chemical-structure-S1531.gif |