Pralatrexate
Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.
| Trivial name | NSC 754230 |
| Catalog Number | S1497 |
| Molecular Formula | C23H23N7O5 |
| CAS# | 146464-95-1 |
| Inchi | InChI=1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t 14?,16-/m0/s1 |
| Inchi Key | OGSBUKJUDHAQEA-WMCAAGNKSA-N |
| SMILES | C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/Pralatrexate(Folotyn).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Pralatrexate-Folotyn-chemical-structure-S1497.gif |