Amuvatinib (MP-470)
Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.
| Trivial name | HPK 56 |
| Catalog Number | S1244 |
| Molecular Formula | C22H23F3N4 |
| CAS# | 850879-09-3 |
| Inchi | InChI=1S/C22H23F3N4/c23-22(24,25)20-18(10-13-29-19(14-15-6-7-15)26-27-21(20)29)28-11-8-17(9-12-28)16-4-2-1-3-5-16/h1-5,10,13,15,17H,6-9,11-12,14H2 |
| Inchi Key | BQAVZGJJQFJSMW-UHFFFAOYSA-N |
| SMILES | C1CC1CC2=NN=C3N2C=CC(=C3C(F)(F)F)N4CCC(CC4)C5=CC=CC=C5 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/MP-470.html |
| Additional Information | https://file.selleck.cn/downloads/struct/MP-470-chemical-structure-S1244.gif |