Amuvatinib (MP-470)
Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.
| Trivial name | HPK 56 |
| Catalog Number | S1244 |
| Molecular Formula | C16H16N6 |
| CAS# | 850879-09-3 |
| Inchi | InChI=1S/C16H16N6/c1-7-17-15(18-8-1)21-11-13-3-5-14(6-4-13)12-22-16-19-9-2-10-20-16/h1-10H,11-12H2,(H,17,18,21)(H,19,20,22) |
| Inchi Key | PXZXYRKDDXKDTK-UHFFFAOYSA-N |
| SMILES | C1=CN=C(N=C1)NCC2=CC=C(C=C2)CNC3=NC=CC=N3 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/MP-470.html |
| Additional Information | https://file.selleck.cn/downloads/struct/MP-470-chemical-structure-S1244.gif |