Amuvatinib (MP-470)

Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.

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Trivial name	HPK 56
Catalog Number	S1244
Molecular Formula	C19H17N7O3
CAS#	850879-09-3
Inchi	InChI=1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
Inchi Key	QTRXIFVSTWXRJJ-UHFFFAOYSA-N
SMILES	CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4
Size	50mg
Supplier Page	http://www.selleckchem.com/products/MP-470.html
Additional Information	https://file.selleck.cn/downloads/struct/MP-470-chemical-structure-S1244.gif