XAV-939
XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.
| Trivial name | NVP-XAV939 |
| Catalog Number | S1180 |
| Molecular Formula | C24H26N4O3S |
| CAS# | 284028-89-3 |
| Inchi | InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22/h1-5,8-12,18,26H,6-7,13-17H2 |
| Inchi Key | XAYGBKHKBBXDAK-UHFFFAOYSA-N |
| SMILES | C1CC1CN2CCN(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C4=CC=CC5=C4N=CC=C5 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/XAV-939.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s1180-xav-939-chemical-structure.png |