Regorafenib
Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.
| Trivial name | Fluoro-Sorafenib, BAY 73-4506 |
| Catalog Number | S1178 |
| Molecular Formula | C16H15N3O2 |
| CAS# | 755037-03-7 |
| Inchi | InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2 |
| Inchi Key | BVRDQVRQVGRNHG-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/BAY-73-4506.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BAY-73-4506-chemical-structure-s1178.gif |