CYC116
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.
| Trivial name | N/A |
| Catalog Number | S1171 |
| Molecular Formula | C27H29F3O6S |
| CAS# | 693228-63-6 |
| Inchi | InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,2 1+,24+,25+,26+,27+/m1/s1 |
| Inchi Key | XTULMSXFIHGYFS-VLSRWLAYSA-N |
| SMILES | CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/CYC116.html |
| Additional Information | https://file.selleck.cn/downloads/struct/CYC116-chemical-structure-S1171.gif |