WZ3146
WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).
| Trivial name | N/A |
| Catalog Number | S1170 |
| Molecular Formula | C24H25ClN6O2 |
| CAS# | 1214265-56-1 |
| Inchi | InChI=1S/C24H25ClN6O2/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29) |
| Inchi Key | APHGZZPEOCCYNO-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/WZ3146.html |
| Additional Information | https://file.selleck.cn/downloads/struct/WZ3146-chemical-structure-S1170.gif |