WZ3146
WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).
| Trivial name | N/A |
| Catalog Number | S1170 |
| Molecular Formula | C27H29F3O6S |
| CAS# | 1214265-56-1 |
| Inchi | InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,2 1+,24+,25+,26+,27+/m1/s1 |
| Inchi Key | XTULMSXFIHGYFS-VLSRWLAYSA-N |
| SMILES | CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/WZ3146.html |
| Additional Information | https://file.selleck.cn/downloads/struct/WZ3146-chemical-structure-S1170.gif |