Lenvatinib
Lenvatinib is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β in cell-free assays. Lenvatinib (E7080) also inhibits FGFR1-4, PDGFR, Kit (c-Kit), RET (c-RET), and shows potent antitumor activities. Phase 3.
| Trivial name | E7080 |
| Catalog Number | S1164 |
| Molecular Formula | C20H24N2OS |
| CAS# | 417716-92-8 |
| Inchi | InChI=1S/C20H24N2OS/c1-4-22(5-2)13-12-21-16-11-10-14(3)20-18(16)19(23)15-8-6-7-9-17(15)24-20/h6-11,21H,4-5,12-13H2,1-3H3 |
| Inchi Key | FBQPGGIHOFZRGH-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/E7080.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7080-chemical-structure-S1164.gif |