PLX-4720
PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.
| Trivial name | N/A |
| Catalog Number | S1152 |
| Molecular Formula | C21H13F3N2O4 |
| CAS# | 918505-84-7 |
| Inchi | InChI=1S/C21H13F3N2O4/c22-21(23,24)12-5-3-6-13(11-12)26-17-16(9-4-10-25-17)19(28)30-20-15-8-2-1-7-14(15)18(27)29-20/h1-11,20H,(H,25,26) |
| Inchi Key | ANMLJLFWUCQGKZ-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(OC2=O)OC(=O)C3=C(N=CC=C3)NC4=CC=CC(=C4)C(F)(F)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/PLX-4720.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PLX-4720-chemical-structure-S1152.gif |