PLX-4720
PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.
| Trivial name | N/A |
| Catalog Number | S1152 |
| Molecular Formula | C17H19N3O2S |
| CAS# | 918505-84-7 |
| Inchi | InChI=1S/C17H19N3O2S/c1-10-8-18-15(11(2)16(10)22-4)9-23-17-19-13-6-5-12(21-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20) |
| Inchi Key | XURCIPRUUASYLR-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(C(=C1OC)C)CSC2=NC3=C(N2)C=C(C=C3)OC |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/PLX-4720.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PLX-4720-chemical-structure-S1152.gif |