SNS-032 (BMS-387032)
SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis.
Trivial name | N/A |
Catalog Number | S1145 |
Molecular Formula | C32H38ClN3O2 |
CAS# | 345627-80-7 |
Inchi | InChI=1S/C32H38ClN3O2/c1-4-7-9-32-34-31(25-10-16-28(17-11-25)37-23-8-22-35(5-2)6-3)24-36(32)27-14-20-30(21-15-27)38-29-18-12-26(33)13-19-29/h10-21,24H,4-9,22-23H2,1-3H3 |
Inchi Key | KJNNWYBAOPXVJY-UHFFFAOYSA-N |
SMILES | CCCCC1=NC(=CN1C2=CC=C(C=C2)OC3=CC=C(C=C3)Cl)C4=CC=C(C=C4)OCCCN(CC)CC |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/SNS-032.html |
Additional Information | https://file.selleck.cn/downloads/struct/SNS-032-BMS-387032-chemical-structure-S1145.gif |