AG-490
AG-490 is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
| Trivial name | Tyrphostin B42, Zinc02557947 |
| Catalog Number | S1143 |
| Molecular Formula | C23H26N6O2 |
| CAS# | 133550-30-8 |
| Inchi | InChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+ |
| Inchi Key | HSKAZIJJKRAJAV-KOEQRZSOSA-N |
| SMILES | CC1=CC(=CC=C1)C=NNC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4 |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/AG-490.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AG-490-chemical-structure-S1143.gif |