Alisertib (MLN8237)

Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3.

Price Not Available 5mg Alisertib (MLN8237) Supplier Page

Trivial name	N/A
Catalog Number	S1133
Molecular Formula	C27H20ClFN4O4
CAS#	1028486-01-2
Inchi	InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
Inchi Key	ZLHFILGSQDJULK-UHFFFAOYSA-N
SMILES	COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC
Size	5mg
Supplier Page	http://www.selleckchem.com/products/MLN8237.html
Additional Information	https://file.selleck.cn/downloads/struct/MLN8237-chemical-structure-S1133.gif