LY294002
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.
| Trivial name | SF 1101, NSC 697286 |
| Catalog Number | S1105 |
| Molecular Formula | C6H11NO2 |
| CAS# | 154447-36-6 |
| Inchi | InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9) |
| Inchi Key | HXEACLLIILLPRG-UHFFFAOYSA-N |
| SMILES | C1CCNC(C1)C(=O)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/LY294002.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LY294002-chemical-structure-S1105.gif |