MK-2206 2HCl
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.
| Trivial name | N/A |
| Catalog Number | S1078 |
| Molecular Formula | C25H21N5O.2HCl |
| CAS# | 1032350-13-2 |
| Inchi | InChI=1S/C25H21N5O.2ClH/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31;;/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31);2*1H |
| Inchi Key | HWUHTJIKQZZBRA-UHFFFAOYSA-N |
| SMILES | C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/MK-2206.html |
| Additional Information | https://file.selleck.cn/downloads/struct/MK-2206-chemical-structure-S1078.gif |