Nutlin-3
Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.
| Trivial name | N/A |
| Catalog Number | S1061 |
| Molecular Formula | C30H30Cl2N4O4 |
| CAS# | 890090-75-2 |
| Inchi | InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37) |
| Inchi Key | BDUHCSBCVGXTJM-UHFFFAOYSA-N |
| SMILES | CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/Nutlin-3.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Nutlin-3-chemical-structure-S1061.gif |