Lenalidomide
Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
| Trivial name | CC-5013 |
| Catalog Number | S1029 |
| Molecular Formula | C5H4O3 |
| CAS# | 191732-72-6 |
| Inchi | InChI=1S/C5H4O3/c6-5(7)4-1-2-8-3-4/h1-3H,(H,6,7) |
| Inchi Key | IHCCAYCGZOLTEU-UHFFFAOYSA-N |
| SMILES | C1=COC=C1C(=O)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/lenalidomide-s1029.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Lenalidomide-chemical-structure-S1029.gif |