Dovitinib (TKI-258)
Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4.
| Trivial name | CHIR-258 |
| Catalog Number | S1018 |
| Molecular Formula | C6H12O2 |
| CAS# | 405169-16-6 |
| Inchi | InChI=1S/C6H12O2/c1-3-5(4-2)6(7)8/h5H,3-4H2,1-2H3,(H,7,8) |
| Inchi Key | OXQGTIUCKGYOAA-UHFFFAOYSA-N |
| SMILES | CCC(CC)C(=O)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/CHIR-258.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Dovitinib-chemical-structure-s1018.gif |