Dovitinib (TKI-258)
Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4.
| Trivial name | CHIR-258 |
| Catalog Number | S1018 |
| Molecular Formula | C4H9NO2 |
| CAS# | 405169-16-6 |
| Inchi | InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7) |
| Inchi Key | FFDGPVCHZBVARC-UHFFFAOYSA-N |
| SMILES | CN(C)CC(=O)O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/CHIR-258.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Dovitinib-chemical-structure-s1018.gif |