Bosutinib
Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.
| Trivial name | SKI-606 |
| Catalog Number | S1014 |
| Molecular Formula | C9H10INO3 |
| CAS# | 380843-75-4 |
| Inchi | InChI=1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1 |
| Inchi Key | UQTZMGFTRHFAAM-ZETCQYMHSA-N |
| SMILES | C1=CC(=C(C=C1CC(C(=O)O)N)I)O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/Bosutinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Bosutinib-SKI-606-chemical-structure-S1014.gif |