Bortezomib
Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
| Trivial name | LDP-341, MLM341, NSC 681239,PS-341, BTZ |
| Catalog Number | S1013 |
| Molecular Formula | C18H34O4 |
| CAS# | 179324-69-7 |
| Inchi | InChI=1S/C18H34O4/c1-3-5-15-21-17(19)13-11-9-7-8-10-12-14-18(20)22-16-6-4-2/h3-16H2,1-2H3 |
| Inchi Key | PYGXAGIECVVIOZ-UHFFFAOYSA-N |
| SMILES | CCCCOC(=O)CCCCCCCCC(=O)OCCCC |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/Bortezomib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Bortezomib-Velcade-chemical-structure-S1013.gif |