Dactolisib (BEZ235)

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.

Price Not Available 50mg Dactolisib (BEZ235) Supplier Page

Trivial name	NVP-BEZ235
Catalog Number	S1009
Molecular Formula	C30H23N5O
CAS#	915019-65-7
Inchi	InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
Inchi Key	JOGKUKXHTYWRGZ-UHFFFAOYSA-N
SMILES	CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
Size	50mg
Supplier Page	http://www.selleckchem.com/products/BEZ235.html
Additional Information	https://file.selleck.cn/downloads/struct/BEZ235-NVP-BEZ235-chemical-structure-S1009.gif