Selumetinib (AZD6244)

Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.

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Trivial name	ARRY-142886
Catalog Number	S1008
Molecular Formula	C17H15BrClFN4O3
CAS#	606143-52-6
Inchi	InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
Inchi Key	CYOHGALHFOKKQC-UHFFFAOYSA-N
SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
Size	500mg
Supplier Page	http://www.selleckchem.com/products/AZD6244.html
Additional Information	https://file.selleck.cn/downloads/struct/AZD6244-Selumetinib-chemical-structure-S1008.gif