ABT-737
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
| Trivial name | N/A |
| Catalog Number | S1002 |
| Molecular Formula | C11H13NNa2O7S2 |
| CAS# | 852808-04-9 |
| Inchi | InChI=1S/C11H15NO7S2.2Na/c1-11(2,3)12(13)7-8-4-5-9(20(14,15)16)6-10(8)21(17,18)19;;/h4-7H,1-3H3,(H,14,15,16)(H,17,18,19);;/q;2*+1/p-2/b12-7-;; |
| Inchi Key | XLZOVRYBVCMCGL-BPNVQINPSA-L |
| SMILES | CC(C)(C)[N+](=CC1=C(C=C(C=C1)S(=O)(=O)[O-])S(=O)(=O)[O-])[O-].[Na+].[Na+] |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/ABT-737.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ABT-737-chemical-structure-S1002.gif |