MLi-2
MLi-2 is an orally active and highly selective inhibitor of LRRK2. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro with IC50 of 0.76 nM, a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 with IC50 of 1.4 nM, and a radioligand competition binding assay with IC50 of 3.4 nM.
| Trivial name | N/A |
| Catalog Number | S9694 |
| Molecular Formula | C21H25N5O2 |
| CAS# | 1627091-47-7 |
| SMILES | CC1CN(CC(C)O1)C2=CC(=NC=N2)C3=N[NH]C4=CC=C(OC5(C)CC5)C=C34 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/mli-2.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s9694-mli-2-chemical-structure.gif |