VH298
VH298 is a potent VHL (Von Hippel-Lindau, the E3 ligase) inhibitor that stabilizes HIF-α. VH298 blocks the VHL:HIF-α interaction with Kd of 90 nM in isothermal titration calorimetry (ITC) and 80 nM in a competitive fluorescence polarization assay. VH-298 can be used in PROTAC technology.
Trivial name | N/A |
Catalog Number | S8449 |
Molecular Formula | C27H33N5O4S |
CAS# | 2097381-85-4 |
SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O |
Size | 25mg |
Supplier Page | http://www.selleckchem.com/products/vh298.html |
Additional Information | https://file.selleck.cn/downloads/struct/s8449-vh298-chemical-structure.gif |