Upadacitinib
Upadacitinib is a selective JAK1 inhibitor which demonstrates activity against JAK1 (0.045 μM) and JAK2 (0.109 μM), with > 40 fold selectivity over JAK3 (2.1 μM) and 100 fold selectivity over TYK2 (4.7 μM) as compared to JAK1.
| Trivial name | ABT-494 |
| Catalog Number | S8162 |
| Molecular Formula | C17H19F3N6O |
| CAS# | 1310726-60-3 |
| Inchi | InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1 |
| Inchi Key | WYQFJHHDOKWSHR-MNOVXSKESA-N |
| SMILES | CCC1CN(CC1C2=CN=C3N2C4=C(NC=C4)N=C3)C(=O)NCC(F)(F)F |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/upadacitinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/abt-494-chemical-structure-s8162.gif |