Floxuridine (FUDR)
Floxuridine (FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.
Trivial name | NSC 27640, Deoxyfluorouridine |
Catalog Number | S1299 |
Molecular Formula | C9H11FN2O5 |
CAS# | 50-91-9 |
Inchi | InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 |
Inchi Key | ODKNJVUHOIMIIZ-RRKCRQDMSA-N |
SMILES | C1C(C(OC1N2C=C(C(=O)NC2=O)F)CO)O |
Size | 10mM/1mL |
Supplier Page | http://www.selleckchem.com/products/Floxuridine.html |
Additional Information | https://file.selleck.cn/downloads/struct/Floxuridine-Fludara-chemical-structure-S1299.gif |