Isuzinaxib (APX-115 free base)

Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.

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Trivial name	Ewha-18278 free base
Catalog Number	S0777
Molecular Formula	C17H17N3O
CAS#	1270084-92-8
SMILES	CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3
Size	5mg
Supplier Page	http://www.selleckchem.com/products/apx-115-free-base.html
Additional Information	https://file.selleck.cn/downloads/struct/s0777-apx-115-free-base-chemical-structure.gif