Gefitinib-based PROTAC 3
Gefitinib-based PROTAC 3 which conjugates an EGFR binding element to a VHL ligand via a linker induces degradation of EGFR and mutants with DC50 of 11.7 nM and 22.3 nM in HCC827(Exon 19 del) and H3255 (L858R) cells, respectively.
| Trivial name | N/A |
| Catalog Number | S0070 |
| Molecular Formula | C47H57ClFN7O8S |
| CAS# | 2230821-27-7 |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCCCCOC4=C(C=C5C(=C4)C(=NC=N5)NC6=CC(=C(C=C6)F)Cl)OC)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/gefitinib-based-protac-3.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s0070-gefitinib-based-protac-3-chemical-structure.gif |