Oroxin B
Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.
| Trivial name | Hypocretin-2 |
| Catalog Number | S9190 |
| Molecular Formula | C27H30O15 |
| CAS# | 114482-86-9 |
| Inchi | InChI=1S/C27H30O15/c28-8-15-19(31)22(34)24(36)26(41-15)38-9-16-20(32)23(35)25(37)27(42-16)40-14-7-13-17(21(33)18(14)30)11(29)6-12(39-13)10-4-2-1-3-5-10/h1-7,15-16,19-20,22-28,30-37H,8-9H2/t15-,16-,19- ,20-,22+,23+,24-,25-,26-,27-/m1/s1 |
| Inchi Key | HAYLVXFWJCKKDW-IJTBWITGSA-N |
| SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)COC5C(C(C(C(O5)CO)O)O)O)O)O)O)O)O |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/oroxin-b.html |
| Additional Information | https://file.selleck.cn/downloads/struct/oroxin-b-chemical-structure-s9190.gif |